The last reason has been important in the struggle between viruses and bacteria. It is even possible that two enzymes work as a dimer to cut the palindromic sequence, further increasing efficiency. This allows researchers to experiment with the creation of various organisms without any problems. With this feature, the size and shape of the inserted DNA can be controlled. Cutting both strands of DNA harms the virus more than cutting one strand. A palindromic sequence also increases the chance that both strands of DNA are cut. The palindromic sequence is important in genetic engineering because it makes insertion and amplification easier. Inverted repeats are close cousins of palindromes. It will be useful for studying human cancers and other diseases associated with palindromes. An exact palindrome is one in which there is no asymmetry in the centre or mismatch in any part of the sequence, such that its reverse compliment reads the same as the original sequence itself 3. Bacteria have evolved to 'disable' bacteria-targeting viruses (bacteriophages) using restriction enzymes that bind to these palindromic sequences. The GAP-Seq approach underscores the importance of developing new tools for identifying and characterizing palindromes, and provides a new strategy to systematically assess palindromes in genomes. This is important during the processes of replication, transcription. It is understood that higher order palindromic sequences could be generated in terms of the basis of the highest prime numbers that make up the palindrome sequence number. It is even possible that two enzymes work as a dimer to cut the palindromic sequence, further increasing efficiency. The significance of this sequence is that the sequences reads same in both the direction. Therefore, important vital functions of a living organisms are protected by means of these symmetric features. This means that the enzyme recognizes the sequence no matter from which side the enzyme approaches the DNA.Ī palindromic sequence also increases the chance that both strands of DNA are cut. A palindromic sequence is the same backwards and forwards on both sides (see image below). Luckily! because you don't want a 'pacman' that cuts DNA at random places.ĭNA is double stranded, so it has 'two sides' to which the enzyme can bind. It binds to the DNA only in one specific configuration. Palindromic sequences are the usual recognition sites for restriction enzymes and frequently occur as essential elements in regulatory regions. Enzymes such as restriction enzymes have to recognize a very specific sequence in order to carry out its task.
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